Cytoplasmic dna sensing
WebIn response to senescence-inducing genotoxic stress, such as radiation and oncogene activation, growth-arrested cells generate cytosolic DNA substrates, which alerts the … WebThe second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These ...
Cytoplasmic dna sensing
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WebBernard-Soulier syndrome (BSS) is an autosomal-recessive bleeding disorder caused by biallelic variants in the GP1BA, GP1BB, and GP9 genes encoding the subunits GPIbα, GPIbβ, and GPIX of the GPIb-IX complex. Pathogenic variants usually affect the extracellular or transmembrane domains of the receptor subunits. We investigated a … WebJun 12, 2024 · The release of DNA into the cytoplasm upon damage to the nucleus or during viral infection triggers an interferon-mediated defense response, inflammation and cell death. In human cells cytoplasmic DNA is sensed by cyclic GMP-AMP Synthase (cGAS) and Absent In Melanoma 2 (AIM2). Here, we report the identification of a “natural …
WebDive into the research topics of 'Cytoplasmic DNA: sources, sensing, and role in aging and disease'. Together they form a unique fingerprint. DNA Medicine & Life Sciences 100%. Inflammation Mediators Medicine & Life Sciences 57%. Therapeutics Medicine & Life Sciences 14%. View full fingerprint ... WebThe cGAS/STING pathway is a cytoplasmic DNA sensor, and activation of the cGAS/STING pathway leads to two independent downstream pathways: type I IFNs through IRF3 and proinflammatory responses through NFκB16. Both the IRF3- and NF-κB-dependent pathways lead to the production of inflammatory growth factors and …
WebMay 5, 2013 · The cytosolic DNA sensing pathways are also likely to feature given the link between TREX1 and autoimmune disease: Lack of TREX1 causes cytosolic … WebMay 5, 2013 · Interestingly, the authors found that in a cell type with limited basal IFI16 expression, DDX41 seemed to be the initial sensor of cytoplasmic DNA, inducing IFN and subsequent IFI16 expression, the latter serving as an amplifier of innate responses (Zhang et al., 2011b). Thus, data from studies involving IFI16 and DDX41 suggest that the …
WebOct 1, 2024 · Cytoplasmic DNA and cytoplasmic DNA-sensing adapter STING play key parts in aortic degeneration by promoting smooth muscle cell damage, matrix metalloproteinase (MMP) production in macrophages ...
WebMar 30, 2024 · We first asked whether cytoplasmic sensors of LPS other than caspase-11 could be detected in innate immune cells. Immunoprecipitates of biotin-labeled LPS from immortalized bone marrow-derived macrophage (iBMDM) cell lysates (Figure 1 A) were analyzed by mass cytometry.Caspase-11 was identified among the most abundant LPS … daniel wallace bible scholarWebApr 13, 2024 · In summary, this study identified KU-mediated cytoplasmic DNA sensing in aged CD4 + T cells as a critical driver for T cell homeostatic proliferation and aging-related autoimmunity. We clearly need this pathway to protect us from infections when we age and no longer have fresh supply of T cells from the thymus. Aged T cells also drive many ... daniel walsh obituaryWebFeb 15, 2013 · To immunologists, DNA has always had a dark side. Long before it was shown to be the genetic material, it was known to stimulate immune responses ( 1 ). When DNA is in the wrong place, it is a sign of danger. The danger can be in the form of infection where microbial DNA is sensed, or cellular damage that leaks DNA into the cytoplasm … daniel wall artistdaniel wallace family mattersWebOct 1, 2024 · Host cytoplasmic DNA sensing is typically prevented since it is usually restricted to the nucleus and mitochondria. However, multiple situations lead to the presence of misplaced DNA and autoimmunity can result from failure to properly dispose it through DNAse activity. Besides cell extrinsic DNAse I, mammalian cells express the … daniel wall artist biographyWebNov 3, 2024 · Chromosomal DNA in the cytoplasm can be generated by chromosome mis-segregation during cell division, such as micronuclei, 28,29 or by nucleus-to-cytoplasm transport of chromatin fragments under ... daniel wall city of vernonWebDec 20, 2012 · Recognition of foreign DNA in intracellular compartments or in the cytoplasm sounds an alarm bell signaling pathogenic invasion. In response, innate immune DNA-sensing pathways launch an antimicrobial type I interferon (IFN) response, which becomes damaging to the host if unregulated or inappropriately activated by self … daniel walsh attorney de pere wi