WebAnth, cyclophosphamide, trastuzumab (in combination or alone) Baseline and 4 mo after treatment initiation: Significant increase in PWV (6.9±2.3 to 13.5±4.7 ms) and decrease in distensibility (4.1±1.6 to 1.9±1.2 mm Hg) … WebFeb 21, 2024 · Cancer patients receiving chemotherapy have an increased risk of developing cardiovascular complications, and the risk is even greater if there is a known history of heart disease. Among the serious complications that have been reported are: Arrhythmias Heart failure Myocardial necrosis causing a dilated cardiomyopathy
Cardiotoxicity Associated With High-Dose …
WebGet medical help right away if you develop: chest pain, jaw/left arm pain, trouble breathing, irregular heartbeat, symptoms of heart failure (such as shortness of breath, swelling … WebIn the initial clinical trials of trastuzumab, use of this agent alone was associated with up to a 2% risk of developing significant cardiac dysfunction (New York Heart Association class III to IV heart failure) and increased to 16% when trastuzumab was used in combination with anthracyclines and cyclophosphamide. 47 In more recent trials ... grand rapids to rapid city
HIGHLIGHTS OF PRESCRIBING INFORMATION Cardiotoxicity
WebAug 11, 2024 · Cyclophosphamide has no known severe interactions with other drugs. Serious interactions of cyclophosphamide include: adenovirus types 4 and 7 live, oral; carbamazepine; ... Acute heart failure, often occurring within 1 to 10 days of treatment, has been reported; Subclinical decreases in left ventricular ejection fraction ... WebAug 19, 2024 · Myocarditis, myopericarditis, pericardial effusion including cardiac tamponade, and congestive heart failure, which may be fatal, have been reported with … grand rapids to savannah georgia flights