Nettet10. feb. 2004 · The inter-alpha-trypsin inhibitor (ITI) family constitutes a group of proteins built up from one light chain and a variable set of heavy chains. Originally … NettetThe inter-α-trypsin inhibitor complex is a macromolecular arrangement of structurally related heavy chain proteins covalently cross-linked to the chondroitin sulfate (CS) chain of the proteoglycan bikunin. The inter-α-trypsin inhibitor complex is abundant in plasma and associated with inflammation, kidney diseases, cancer and diabetes.
Structure and Function of Inter--Trypsin Inhibitor Heavy Chains
NettetInter-alpha-trypsin inhibitor heavy chain H3 is a protein that in humans is encoded by the ITIH3 gene. [5] [6] [7] See also [ edit] Inter-alpha-trypsin inhibitor ITIH1 ITIH2 ITIH4 References [ edit] ^ a b c GRCh38: Ensembl release 89: ENSG00000162267 - Ensembl, May 2024 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006522 - Ensembl, … Inter-alpha-trypsin inhibitors (IαI) are plasma proteins consisting of three of four heavy chains selected from the group ITIH1, ITIH2, ITIH3, ITIH4 and one light chain selected from the group AMBP or SPINT2. They function as protease inhibitors. IαI form complexes with hyaluronan (HA), generating a serum-derived hyaluronan-associated protein (SHAP)-HA complex. The SHAP-HA complex is found in very high concentration in rheu… how to use love alpha fiber mascara
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Nettet9. okt. 2024 · Overproduction of inter-α-trypsin inhibitor heavy chain 1 after loss of Gα 13 in liver exacerbates systemic insulin resistance in mice The impact of liver disease … NettetInter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene. [5] [6] [7] It is known to contain a Gla domain, and thus be dependent for production on post translational modification requiring vitamin K. Its function is also presumably dependent on calcium ions. See also [ edit] Inter-alpha-trypsin inhibitor Nettet23. feb. 2024 · Inter-alpha-trypsin inhibitor heavy chain H5 −4.4 RBP4 Retinol-binding protein 4 2.8 APOA1 Apolipoprotein A-I −3.8 COL1A2 Collagen alpha-2(I) chain 2.6 ADAMTS1 A disintegrin and metalloproteinase with thrombospondin motifs 1 −3.4 LTF Lactotransferrin 2.3 B4GALT1 Beta-1,4-galactosyltransferase 1 −3.3 APOC3 organism classification chart