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Kif11 control

Web6 jul. 2015 · PLK1 inhibition causes transient monopolar spindles. 3D Time-lapse imaging in control and BI 2536 treated live mouse oocytes expressing KIF11-mEGFP (green, spindle poles) and mCherry-MAP4... Web17 okt. 2006 · Description. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. …

Silencer ™ KIF11 (Eg5) siRNA (human, mouse, rat)

Web29 jan. 2024 · During mitosis, Kif11, a kinesin motor protein, promotes bipolar spindle formation and chromosome movement, and during interphase, Kif11 mediates diverse … WebQuality Control Testing: 12.5% SDS-PAGE Stained with Coomassie Blue. Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. ... KIF11; Gene Alias: EG5,HKSP,KNSL1,TRIP5; Gene Description: kinesin family member 11; Omim ID: 148760; Gene Ontology: Hyperlink; javascript programiz online https://prediabetglobal.com

KIF11 silencing and inhibition induces ... - Wiley Online Library

Web3 jul. 2024 · KIF11 knockdown remarkably suppressed thyroid cancer cell proliferation as well as induced cell apoptosis of thyroid cancer cells, suggesting that KIF11 may be a potential therapeutic target for thyroid cancer. 2. Materials and Methods 2.1. Antibodies, Primers, and Plasmids Web19 sep. 2024 · I Cell sensitivity to SB743921 treatment in control and KIF11-knockdown cells. CCLP1 and TFK1 cells transfected with indicated siRNA or NC were exposed to SB743921 for 72 h. Web9 mei 2024 · EG5 (KIF11) is a member of the kinesin-like protein family involved in centrosome separation and bipolar spindle formation. When a cell enters mitosis, CDK1 phosphorylates EG5 at Thr926 and promotes EG5 localization on the mitotic spindle which drives bipolar spindle formation. EG5 provides power fo … javascript print image from url

KIF11 Functions as an Oncogene and Is Associated with Poor

Category:KIF11 Functions as an Oncogene and Is Associated with Poor

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Kif11 control

KIF11 Is a Promising Therapeutic Target for Thyroid Cancer

WebAmbion™ Silencer ™ KIF11 (Eg5) Positive Control siRNA (Human, Mouse, Rat) is ideal for developing and optimizing siRNA experiments. 5 nmol is provided, along with an … Web29 mrt. 2024 · KIF11 mutations are known to cause autosomal dominant microcephaly-lymphedema-chorioretinopathy dysplasia syndrome, associated or not with intellectual disability. We report a father and two ...

Kif11 control

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Web18 aug. 2024 · KIF11 has been demonstrated to have microtubule polymerase activity, as well as to control axon growth 7,8. It has also been shown to mediate centrosome … WebSilencer® KIF11 (Eg5) siRNA (Human, Mouse, Rat) Store at or below –20°C. Do not store in a frost-free freezer. Catalog #: AM4639 Component: KIF11 (Eg5) siRNA Negative Control #1 siRNA Amount: 5 nmol 2 nmol Volume: 100 μL 40 μL Concentration: 50 μM 50 μM Target Information: Gene Symbol: KIF11 Full Gene Name: Kinesin family member 11

Web4 jan. 2024 · Co-targeting KIF11 and BRD4 with ARRY-520 and JQ1 reduced MPNST cell viability, synergistically killing a much higher proportion of MPNST cells than control … WebAdenomatous polyposis coli (APC) also known as deleted in polyposis 2.5 (DP2.5) is a protein that in humans is encoded by the APC gene. The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion.Mutations in the APC gene may result in colorectal cancer.. APC is …

Web21 mrt. 2024 · KIF11 (Kinesin Family Member 11) is a Protein Coding gene. Diseases associated with KIF11 include Microcephaly With Or Without Chorioretinopathy, … Web11 apr. 2024 · Identification of exosomes and expression of miR-619-5p. A The morphology of cell exosomes was observed by the transmission electron microscope at 120 kv.B identification of exosomes by Western blot, CD63 as positive marker and Calnexin as negative marker.C and D Detection of miR-619-5P expression in GC cells and their …

WebProduct Description: Ambion Silencer® KIF11 (Eg5) siRNA Control is ideal for developing and optimizing siRNA trans ection conditions. It can also be used as a control in siRNA …

Web2 jun. 2024 · KIF11 is needed for bipolar spindle formation in metaphase. We identified KIF11 as a universal target of all ATRT-molecular-subtypes. Ispinesib, a KIF11-inhibitor, effectively inhibited tumor... javascript pptx to htmlWebOur data provide extensive evidence to demonstrate that KIF11 inhibitors showed pronounced antitumor activity, acting in key points of tumorigenesis and cancer progression in in vivo xenograft... javascript progress bar animationInhibitors of KIF11 have been developed as chemotherapeutic agents in the treatment of cancer. Drugs that specifically inhibit only human Kinesin-5 are alternatives to the taxanes and vinc alkaloids that target microtubules, and thus all cells, and that are currently used clinically. Inhibition of Kinesin-5 causes cells to undergo mitotic arrest, undergo apoptosis and form monoaster spindles. The first KIF11 inhibitor, monastrol was discovered in a chemical screen of … javascript programs in javatpoint