Phosophosulindac
WebPhospho-sulindac is a sulindac derivative with promising anticancer activity in lung cancer, but its limited metabolic stability presents a major challenge for systemic therapy. We reasoned that inhalation delivery of phospho-sulindacmight overcome first-passmetabolismand produce high levels of intact drug in lung tumors. Here, we developed … WebPhospho-sulindac (P-S), a promising anticancer agent, is efficacious in pre-clinical models of human cancer and is apparently safe. Here, we studied the effect of P-S on pancreatic cancer growth.
Phosophosulindac
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WebFeb 25, 2024 · The prominent transformation of PS is its rapid hydrolysis, mainly at its carboxylic ester, by carboxylesterases encountered in the intestinal mucosa and blood, and a series of metabolic transformations dominated by the fate of its main metabolite, sulindac. WebSep 9, 2014 · Phospho-sulindac amide (PSA) is a novel potential anti-cancer and anti-inflammatory agent. Here we report the metabolism of PSA in vitro. PSA was rapidly …
WebABSTRACT The treatment of dry eye disease (DED) has been hampered by weak agents, significant side effects and high cost. The pathophysiological hallmark of DED that unifies its diverse etiologies WebDec 29, 2024 · We investigated the therapeutic effect of the novel anti-inflammatory drug phosphosulindac (PS) in rabbit models of DED encompassing its pathogenesis, and its transition to chronicity. Methods:...
WebJun 22, 2012 · Phospho-sulindac (OXT-328) was a gift from Medicon Pharmaceuticals, Inc, Setauket, NY. Its partition coefficient (LogP) between octanol and water was determined to be 3.91. Stearic acid, lecithin, chloroform, and Myrj59 were purchased from Sigma-Aldrich. Cell culture reagents were purchased from American Type Culture Collection. SLN-PS …
Web45 Ludlow St Ste 504 Yonkers, NY 10705 Phone+1 914-963-3232 Fax+1 914-968-5656 Is this information wrong? Summary Dr. Yu Sun, MD is a family physician in Yonkers, New York. He is currently licensed to practice medicine in New York, Connecticut, and Pennsylvania. grand villa burnaby atlasWebAug 1, 2024 · Phosphosulindac (PS, OXT-328) is a small molecule whose salient features, based on extensive preclinical work, are its pharmacologic efficacy and outstanding … chinese tassels for saleWebJul 5, 2011 · The nonsteroidal anti-inflammatory drug (NSAID) sulindac and the ornithine decarboxylase (ODC) antagonist difluoromethylornithine (DFMO), individually and together, are effective inhibitors of colon carcinogenesis. However, chronic use of sulindac is associated with significant side effects. chinese taro root cake recipeWebFeb 1, 2012 · A significant development in combination chemoprevention is the use of sulindac plus difluoromethylornithine (DFMO), which was recently demonstrated to reduce the recurrence of all human colon adenoma... grand villa casino burnaby jobsWebThe SLN used in this work encapsulated phospho-sulindac was evaluated in human lung cancer xenograft models. 68 Lung cancers are usually labeled as mutations in the p53 gene, resulting in loss of mutational repair and tumor-suppressor function, inhibition of apoptosis, increased tumor angiogenesis, cell proliferation, and increased drug ... grand villa casino burnaby hotelWebSulindac C20H17FO3S CID 1548887 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety ... chinese tartaryWebJerrold Rosenbaum, MD, talks to WBUR about the new Center for the Neuroscience of Psychedelics. The center will focus on studying how and why the brain reacts to … chinese tarot reading jui guoliang