Phosphopantetheine adenylyltransferase
Webpantetheine adenylyltransferase (PPAT), which catalyzes the penultimate step in the pathway (Fig. 1), the reversible adeny-lation of 49-phosphopantetheine to form 39 … WebApr 15, 1999 · Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in bacteria that catalyses a rate-limiting step in coenzyme A (CoA) biosynthesis, by transferring an adenylyl group from ATP to 4′-phosphopantetheine, yielding dephospho-CoA (dPCoA). Each phosphopantetheine adenylyltransferase (PPAT) subunit displays a dinucleotide …
Phosphopantetheine adenylyltransferase
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WebMay 30, 2024 · In this study, phosphopantetheine adenylyltransferase (PPAT/CoaD) enzyme, involved in the coenzyme A biosynthesis pathway, was evaluated in the context of fragment-based discovery of new inhibitors targeting Mycobacterium abscessus. The structures of PPAT from M. abscessusMab PPAT, facilitating the initiation of a structure … WebFeb 9, 2024 · Generally, CoA is synthesised from pantothenate (vitamin B 5) in five steps. 7 Phosphopantetheine adenylyltransferase (PPAT), a hexameric protein encoded by the coaD gene, catalyses the penultimate step—the transfer of an adenylyl group from ATP to 4′-phosphopantetheine, to form dephospho-CoA and pyrophosphate.
WebMar 25, 2024 · Abstract Crystals of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis (PPATMt), which were grown using 2-methyl-2,4-pentanediol (MPD) or ammonium sulfate as the precipitant, belong to sp. grs. R32 and Р32, respectively. Crystals of the enzyme containing the ligand in the active site were obtained by the … WebSep 18, 2024 · Crystal structure of the complex of phosphopantetheine adenylyltransferase from Acinetobacter baumannii with Phosphonoacetate at 2.19 A resolution. DOI: 10.2210/pdb6KYG/pdb Deposited: 2024-09-18 Released: 2024-10-09
WebNational Center for Biotechnology Information WebAug 31, 2015 · Inside the cell, 4′-phosphopantetheine was enzymatically converted back to CoA by the bifunctional enzyme CoA synthase. Phenotypes induced by intracellular CoA deprivation were reversed when...
WebMar 24, 2010 · To identify the phosphopantetheine adenylyltransferase sub-site bound by these inhibitors, two techniques were utilized: steady-state enzyme kinetics and a novel 19 F NMR method in which fluorine-containing fragments that bind the ATP and/or phosphopantetheine sites serve as competitive reporter probes. These data are …
WebIn enzymology, a pantetheine-phosphate adenylyltransferase ( EC 2.7.7.3) is an enzyme that catalyzes the chemical reaction. ATP + 4'-Phosphopantetheine diphosphate + 3' … phoebe\u0027s canterburyttc cherry streetWebProtein target information for Phosphopantetheine adenylyltransferase (Vibrio vulnificus YJ016). Find diseases associated with this biological target and compounds tested … phoebe\\u0027s cat songWebSep 1, 1999 · Phosphopantetheine adenylyltransferase (PPAT) catalyzes the penultimate step in coenzyme A (CoA) biosynthesis: the reversible adenylation of 4'-phosphopantetheine yielding 3'-dephospho-CoA and pyrophosphate. Wild-type PPAT from Escherichia coli was purified to homogeneity. phoebe\\u0027s christmas song backing trackWebPhosphopantetheine adenylyltransferase (PPAT) cat-alyzes the penultimate step in coenzyme A (CoA) biosyn-thesis: the reversible adenylation of 4*-phosphopante-theine yielding 3*-dephospho-CoA and pyrophosphate. Wild-type PPAT from Escherichia coli was purified to homogeneity. N-terminal sequence analysis revealed ttcc lawbotsWebThe coenzyme A (CoA) biosynthesis pathway has attracted attention as a potential target for much-needed novel antimicrobial drugs, including for the treatment of tuberculosis (TB), the lethal disease caused by Mycobacterium tuberculosis (Mtb). Seeking to identify inhibitors of Mtb phosphopantetheine … phoebe\u0027s cat songWebInhibitors of 4′-phosphopantetheine adenylyltransferase (PPAT) were identified through high-throughput screening of the AstraZeneca compound library. One series, cycloalkyl pyrimidines, showed... phoebe\\u0027s canine resort seneca falls